autoreactive in a sentence
1) May play a role in autoreactive B-cells removal.
2) This serves as a germinal centre survival signal for autoreactive B-cells.
3) Development of autoimmune-mediated inflammation mostly depends on the cytokine profile produced by autoreactive T cells.
4) In the presence of autoreactive T cells, a chronic autoimmune disease may be the consequence.
autoreactive example sentences
5) autoreactive B cells can accidentally emerge during somatic hypermutation and migrate into the germinal center light zone.6) In EAM, IL-17A is one of the major cytokines produced by autoreactive T cells.
7) Just as in T cells, clonal deletion and clonal anergy can physically eliminate autoreactive B cell clones.
8) Central tolerance refers to the tolerance established by deleting autoreactive lymphocyte clones before they develop into fully immunocompetent cells.
9) Furthermore, activation of autoreactive Th cells requires presentation of the self-antigen by antigen-presenting cells such as dendritic cells.
10) Together with the concept of T-cell-B-cell discordance this idea forms the basis of the hypothesis of self-perpetuating autoreactive B cells.
11) The T cells recognize myelin as foreign and attack it, explaining why these cells are also called "autoreactive lymphocytes".
12) Wang, Y. and Diamond, B. B cell receptor revision diminishes the autoreactive B cell response after antigen activation in mice.
13) The events that lead to Treg failure in controlling autoreactive effector T cells (Teffs) during autoimmunity are not completely understood.
14) autoreactive cells, such as the ones that interact with the brain for instance, are not eradicated, but can also be found in normal individuals.
example sentences with autoreactive
15) To describe a disease as autoimmune requires the demonstration of autoreactive lymphocytes or autoantibodies, or both, which are specific to that disease.16) autoreactive B cells, maturated coincidentally, normally do not receive survival signals by antigen planted on follicular dendritic cells, and perish by apoptosis.
17) Venkatesh, J., Peeva, E., Xu, X. and Diamond, B. Hormonal milieu, not antigenic specificity, determines the mature phenotype of autoreactive B cells.
18) Chu, YP., Spatz, L., and Diamond, B. A second heavy chain permits survival of high affinity autoreactive B cells.
19) Grimaldi, CM., Michael, DJ., and Diamond, B. Expansion and activation of a population of autoreactive marginal zone B cells in a model of estrogen-induced lupus.
20) This inducer of autoimmunity causes autoreactive T cells to be activated de novo by self epitopes released secondary to pathogen-specific T cell-mediated bystander damage.
21) Weakly autoreactive B cells may also remain in a state of immunological ignorance where they simply do not respond to stimulation of their B cell receptor.
22) This expression in the thymus, allows for the deletion of autoreactive thymocytes by exposing them to self-antigens during their development, a mechanism of central tolerance.
23) This involves selection of T-cells that are "functional (positive selection)", and elimination of T-cells that are "autoreactive (negative selection)".
24) This process is error-prone, and some thymocytes fail to make functional T-cell receptors, whereas other thymocytes make T-cell receptors that are autoreactive.
25) Caforio et al. demonstrated that autoreactive antibodies against cardiac α-myosin are frequently present in patients with myocarditis [ 30 ].
26) Until relatively recently, it was believed that the self/non-self discrimination was a simple matter of eradicating autoreactive cells in the thymus.
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