autophagosome in a sentence
1) Once the mTORC1 kinase activity is inhibited, autophagosome formation occurs.
2) The LC3 system is important for transport and maturation of the autophagosome.
3) The autophagosome then fuses with a lysosome and its cargo is degraded and recycled.
4) Within the lysosome, the contents of the autophagosome are degraded via acidic lysosomal hydrolases.
autophagosome example sentences
5) autophagosome formation also requires Atg12 and LC3, protein conjugation systems that resemble ubiquitin.6) Once an autophagosome has matured, it fuses its external membrane with lysosomes to degrade its cargo.
7) This involves the formation of a double membrane around cytoplasmic substrates resulting in the organelle known as an autophagosome.
8) At this time point, there was an accumulation of autophagy substrates and the formation of abnormally large autophagosomes.
9) The lipidated form of LC3, known as LC3-II, is attached to the autophagosome membrane.
10) Research by Wang "et al" finds that infected cells lead to higher levels of autophagosomes in normal and infected cells.
11) One of the mechanisms of programmed cell death (PCD) is associated with the appearance of autophagosomes and depends on autophagy proteins.
12) The autophagosome travels through the cytoplasm of the cell to a lysosome, and the two organelles fuse; intersection with endosomal pathways also occurs.
13) During this process, targeted cytoplasmic constituents are isolated from the rest of the cell within a double-membraned vesicle known as an autophagosome.
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