autoinhibitory in a sentence
1) The phosphorylated activation loops also render the kinase insensitive to the presence of its autoinhibitory domain.
2) That is, the carboxy-terminal portion of each subunit folds up onto itself in an autoinhibitory manner stabilizing the monomeric subunits.
3) These Raf genes encode severely truncated proteins, that lack the entire N-terminal autoinhibitory domain, and the 14-3-3 binding motifs.
4) The most important regulatory mechanism involves the direct, physical association of the N-terminal autoinhibitory block to the kinase domain of c-Raf.
autoinhibitory example sentences
5) An ultrasensitive switch has been engineered by combining a simple linear signaling protein (N-WASP) with one to five SH3 interaction modules that have autoinhibitory and cooperative properties.6) After the autoinhibitory CR1 regulatory domain is released, B-Raf's CR3 kinase domain must change to its ATP-binding active conformer before it can catalyze protein phosphorylation.
7) This "closed" state can only be relieved if the autoinhibitory domain of Raf engages a partner competing with is own kinase domain, most importantly GTP-bound Ras.
8) Between the autoinhibitory domain block and the catalytic kinase domain, a long segment - characteristic to all Raf proteins - can be found.
9) Historically, this autoinhibitory block was labelled as the CR1 region ("Conserved Region 1"), the hinge region being named CR2, and the kinase domain CR3.
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